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KMID : 0604520180440010009
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Journal of the Society of Cosmetic Scientists of Korea
2018 Volume.44 No. 1 p.9 ~ p.14
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A Study on the Whitening Activities of Gentiana scabra Extract
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Lee Hyun-Sang
Seok Ji-Hyun
Ting Cheung Wai
Kim Yun-Jeong
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Abstract
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In order to find new functional materials for the cosmetics application, we investigated the anti-oxidant and anti-melanogenic properties of Gentiana scabra extracts (GSE), which were prepared by the various extraction methods. Results showed that GSE had high DPPH radical scavenging activity in a dose-dependent manner. Also, GSE inhibited the prodution of melanin in B16F10 melanoma cell as well as tyrosinase activity. We also found that GSE inhibited mRNA expression of tyrosinase-related protein (TRP)-1 and 2. In conclusion we suggest that GSE is applicable to cosmetics as a potential ingredient for their anti-oxidant and whitening effects.
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KEYWORD
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Gentiana scabra extract, anti-oxidant, whitening, tyrosinase, melanin
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